Adrenocorticotropic hormone(ACTH 1-39) peptide, or corticotropin, a peptide of 39 amino acids, is first synthesized as a larger precursor from which ACTH is derive by proteolytic cleavage. ACTH stimulates production of glucocorticoids from the adrenal cortex. Release of ACTH depends on diurnal rhythms with serum levels highest in the early morning. Secretion of this peptide also increases under stress. It is easier and less expensive to treat patients having adrenocortical insufficiency with glucocorticoid replacement therapy than it is to use ACTH.
Adrenocorticotropic hormone benefits
Therefore, use of ACTH (Acthar) is restrict to diagnosis; a shorter 24–amino acid analogue (Cosyntropin) is also used. Intravenous administration of ACTH should result in peak plasma levels of glucocorticoids within 30 to 60 minutes if the adrenal gland is functional. Prolonged administration of ACTH in a repository form, however, may be necessary to stimulate steroid production, because ACTH has long-term trophic effects on adrenal cells in addition to the rapid stimulation of steroid production. If the cause of steroid deficiency is at the level of the pituitary gland, ACTH should eventually stimulate steroid production.
Biological Functions
The main function of Adrenocorticotropic hormone (ACTH) is to regulate the glucocorticoid (steroid) hormone cortisol. Cortisol releas by the adrenal gland. It regulates blood pressure, blood sugar, the immune system, and the response to stress. This test can help find the causes of certain hormone problems adrenocorticotropic hormone function
Health Hazard buy Adrenocorticotropic Hormone (ACTH;Adrenocorticotropin; corticotropic hormone): (1)Maintenance of adrenal cortex;(2)Promotes secretion of steroids, oxidative phosphorylation in adrenal cortex;(3)Mobilizes and increases oxidation of free fatty acid in adipose tissue;(4)Increases gluconeogenesis in liver; increases cyclic adenosine monophosphate (AMP) in adrenal cortex;Decreases urea formation in liver.
Biochem/physiol Actions Stimulates synthesis and secretion of glucocorticoids by adrenal cortex.
Producing and consuming organs The anterior pituitary produces ACTH. It consider a tropic hormone. Tropic hormones indirectly affect target cells by first stimulating other endocrine glands. Corticotropin-releasing hormone (CRH) release from the hypothalamus, which stimulates the anterior pituitary to release adrenocorticotropic hormone (ACTH). ACTH then acts on its target organ, the adrenal cortex.
adrenocorticotropic hormone stimulation test Chemical Properties
storage temp. −20°C
form powder
InChIKey XFBDTKGDXZDJAN-WODOTNDISA-N
Safety Information
Hazard Codes Xn
Risk Statements 20/21/22-40
Safety Statements 22-36
WGK Germany 3
More Introduction:https://en.wikipedia.org/wiki/Adrenocorticotropic_hormone
