Sibutramine has been used to produce appetite suppression for the purpose of attaining weight loss in the treatment of patients with obesity.Sibutramine has usually been used in the form of the hydrochloride monohydrate salt.
sibutramine hydrochloride uses
what is Sibutramine hydrochloride is a weight loss drug, it is hydrochloride salt form of sibutramine , and the pharmacological effects are fully consistent with of sibutramine , but the stability and solubility are better than sibutramine.
It is firstly used to treat depression, in their clinical application process , people find that the effect of weight loss is significantly stronger than the effect of the antidepressant . On one hand ,by inhibiting the reuptake of serotonin, which makes the body reduce hunger, it can suppress appetite and control caloric intake effectively ; on the other hand, by activating the adrenergic receptors, which increases adipose tissue consumption, it can increase metabolism and energy consumption;it has obvious weight loss effect, sibutramine hydrochloride side effects such as high blood pressure, high heart rate, anorexia, insomnia, abnormal liver function.
Precautions
Sibutramine hydrochloride belongs to the serotonin and norepinephrine reuptake inhibitors, it has the dual role of inhibiting appetite and enhancing metabolism, it can be used for the treatment of obesity which diet and exercise can not control.
There are many taboos in clinical practice of It , for example, patients with severe hypertension or patients with severe liver and kidney dysfunction, or patients with angle-closure glaucoma and women after childbirth, should not use it . Because the physiological effects of 16 years old or younger minors have not yet been confirmed, use of it should be prohibited. Also doses should be strictly controlled by users, the recommended starting dose is 10 mg per day for adults, the maximum should not exceed 15 mg. If there is overdose, patients should go to hospital for treatment, there is no specific antidote. Only symptomatic treatment can be taken in clinic.
English name:Sibutramine hydrochloride powder
Melting point 190-200°C
storage temp. room temp
solubility Soluble to 5 mM in water and to 100 mM in DMSO
form Powder
CAS DataBase Reference 84485-00-7(CAS DataBase Reference)
FDA UNII 9GG866ZP1E
More Introduction:https://en.wikipedia.org/wiki/Sibutramine
