what is Testosterone cypionate, sold under the brand name Depo-Testosterone among others, is an androgen and anabolic steroid (AAS) medication which is used mainly in the treatment of low testosterone levels in men. It is also used in hormone therapy for transgender men. It is given by injection into muscle or subcutaneously, once every one to four weeks, depending on clinical indication.
Side effects
testosterone cypionate side effects include symptoms of masculinization like acne, increased hair growth, voice changes, and increased sexual desire.[4] Testosterone supplementation is also known to reduce the threshold for aggressive behavior in men. The drug is a synthetic androgen and anabolic steroid and hence is an agonist of the androgen receptor (AR), the biological target of androgens like testosterone and dihydrotestosterone (DHT). It has strong androgenic effects and moderate anabolic effects, which make it useful for producing masculinization and suitable for androgen replacement therapy. Testosterone cypionate is a testosterone ester and a long-lasting prodrug of testosterone in the body. Because of this, it is considered to be a natural and bioidentical form of testosterone.
Testosterone cypionate was introduced for medical use in 1951.[Along with testosterone enanthate, testosterone undecanoate, and testosterone propionate, it is one of the most commonly used testosterone esters. It is used mainly in the United States. In addition to its medical use, testosterone cypionate is used to improve physique and performance.
Description
Testosterone cypionate is an anabolic steroid that is classified as a male hormone (androgen). Testosterone cypionate is an injectable solution whose brand name is Depo-testosterone. The generic drug is administered to enhance performance in athletics and bodybuilding, and as a prescription drug that alleviates the symptoms of hypogonadism in men. In most cases, the drug is administered to the muscle or the subcutaneous layer of the skin through an injection based on clinical indications or once every few weeks. The androgenic/anabolic structure of Testosterone cypionate has a score of 100, which makes it an appropriate steroid for strength and size associated gains. Testosterone cypionate influences changes in the size, shape, number, and appearance of muscle fibers.
Mechanism of Action In humans
The influence of testosterone may take place based on two mechanisms: through alteration of the hormone to estradiol and trigger specific estrogen receptors, and by triggering of the androgen receptor. Free testosterone (T) is transmitted to the cytoplasm of selected cells for attachment with the androgen receptor, or diminution to 5α-dihydrotestosterone (DHT) through the cytoplasmic enzyme 5α-reductase.
DHT creates a strong bond with a similar androgen receptor, one that is stronger than free testosterone to enhance its androgenic potency. The DHT-receptor or the T-receptor undergoes structural modifications that allow its free flow into the nucleus of the cell for binding with certain nucleotide sequences particular to the chromosomal DNA. Notably, these binding spots are referred to as hormone response elements (HREs), and their effect on the transcriptional activity of specific genes results in the androgenic effects.
When TC is absorbed into the body, the drug is processed in the blood and 40% of the resultant testosterone binds with plasma globulin, the remaining 2% either binds with proteins such as albumin or it remains unbound.
Information on Dosing
The dosage requirements of TC are dependent on an individual’s age, the need for testosterone therapy, the intensity of the condition, additional medical conditions and one’s reaction after injection of the first dose. For primary hypogonadism and hypogonadotropic hypogonadism, 50-400mg is injected into one’s gluteal muscle every 2-4weeks.
The administration of Testosterone cypionate to enhance performance may necessitate a weekly injection of the hormone, where two smaller injections could be more effective. Noteworthy, multiple injections ensure that an individual’s blood levels are at a peak, which mitigates the effects of performance level dosage instructions. In this case, the administration of smaller doses of the hormone may range from 200mg-1000mg per week, which is solely dependent on an individual’s needs.buy testosterone cypionate online.
Interactions Testosterone cypionate can interact with herbs, vitamins and other medications that one may be taking. Such interactions may inhibit the appropriate functionality of the drug hence to avoid this, it is advisable to consult a doctor for management of medications. Notably, some of the drug interactions may include oral blood thinners, adrenocorticotropic and corticosteroid hormones, oral diabetes drugs and insulin.
Indications In men, Testosterone cypionate is indicated for primary or secondary hypogonadism. The testosterone cypionate injection should only be used to treat specific symptoms of testosterone deficiency. Before the initiation of Testosterone cypionate treatment, testosterone deficiency should be validated by clinical features and biochemical assays.
Contraindications
Testosterone cypionate is contradicted in persons who have known or suspected breast and testicular carcinomas. If one is allergic to testosterone they should refrain from the use of Testosterone cypionate. Females should keep off the drug especially if one is either breastfeeding or pregnant.
Side Effects The common side effects associated with testosterone cypionate include : headaches, mood swings. Erections which last longer than normal, frequent erections, gynecomastia, hair growth. Pain and swelling at the point of injection, acne, retention of excess water. And a reduction of the sperm count when one indulges in high dosages of the drug.
Serious side effects of testosterone cypionate use include: aromatization, heart attack, stroke, prostate cancer, liver problems, deep vein thrombosis, pulmonary embolism, polycythemia. And enlargement of the prostate gland.testosterone cypionate injection
TC is well-tolerated amongst most men hence the common side effects can be controlled easily while the serious side effects are not guaranteed.
Testosterone Cypionate Warnings Before
Administering Testosterone cypionate, one should take into consideration the fact that people with liver problems may experience liver damage, people with heart and kidney problems may experience water and salt retention. For people with breast cancer, prostate cancer, sleep apnea, polycythemia, high cholesterol levels and blood clots, TC may amplify their respective conditions.
It is not advisable for seniors above the age of 65 to take Testosterone cypionate. As it may increase their chances of contracting prostate cancer, heart disease or an enlarged prostate. The drug should only be used by males.
Chemical PropertiesTestosterone cypionate is a white or creamy white crystalline powder, odorless or nearly so and stable in air. It is insoluble in water, freely soluble in alcohol, chloroform, dioxane, ether, and soluble in vegetable oils.
Therapeutic Function Androgen
Veterinary Drugs and Treatments. The use of injectable esters of testosterone in veterinary medicine. It is limited primarily to its use in dogs (and perhaps cats). For the treatment of testosterone-responsive urinary incontinence in neutered males. Testosterone has been used to treat a rare form of dermatitis (exhibited by bilateral alopecia) in neutered male dogs. These drugs are also used in bovine medicine to produce an estrus-detector (teaser) animal in cull cows, heifers, and steers.
The effectiveness of testosterone to increase libido, treat hypogonadism, aspermia, and infertility in domestic animals has been disappointing.
half life testosterone cypionate eight days
Testosterone cypionate Chemical Properties
Melting point 101-102°
alpha D25 +87° (CHCl3)
Boiling point 492.01°C (rough estimate)
density 0.9795 (rough estimate)
refractive index 1.5460 (estimate)
storage temp. 2-8°C
solubility DMF: 25 mg/mL; DMSO: 5 mg/mL; Ethanol: 15 mg/mL; Ethanol:PBS (pH 7.2)(1:2): 0.3 mg/mL
form A crystalline solid
InChIKey HPFVBGJFAYZEBE-ZLQWOROUSA-N
SMILES [C@@]12([H])CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])CC[C@]1(C)[C@H](CC[C@@]21[H])OC(=O)CCC1CCCC1 |&1:0,10,12,16,18,21,r|
CAS DataBase Reference 58-20-8(CAS DataBase Reference)
NIST Chemistry Reference Testosterone cypionate(58-20-8)
More Introduction:https://en.wikipedia.org/wiki/Testosterone_cypionate
