letrozole tablets
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letrozole

CAS: 112809-51-5

Product Name: Letrozole
Synonyms: LetrozoleUsp28;Letrozole99%;CGS-20267, Femara;LETRAZOLE;letrozolex;Lelrozol;1-[BIS(4-CYANOPHENYL)METHYL]-1,2,4-TRIAZOLE;4,4′-(1H-1,2,4-Triazol-1-ylmethylene)dibenzonitrile
MF: C17H11N5
MW: 285.3
EINECS: 675-034-8
Product Categories: Anti-cancer&immunity;Aromatics;APIs;Antibiotics;Heterocycles;ELOXATIN;Pharmaceutical material and intermeidates;Active Pharmaceutical Ingredients;All Inhibitors;anti-neoplastic;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;API’s;Anti-Cancer;Letrozole;Antineoplastic;112809-51-5
Mol File: 112809-51-5.mol

letrozole Price(USD):$200/100g $900/500g $1700/1kg
Categories: ,
Letrozole uses is part of a new generation of highly selective aromatase inhibitors and is an artificially synthesized benzotriazole derivative. Letrozole inhibits aromatase to lower estrogen levels, thus preventing estrogen from stimulating tumor growth. Its in vivo activity is 150-250 times stronger than that of first generation aromatase inhibitor Amarante. As it is highly selective, it will not impact glucocorticoid, mineralocorticoid and thyroid functions; even at high dosages, it will not have any inhibiting effects on adrenal corticosteroid secretion, giving it a high treatment index. It has no latent toxicity towards any bodily systems and target organs, has no mutagenicity and carcinogenic effects, has minimal toxic side effects, is well-tolerated, and has stronger anticancer effects than other aromatase inhibitors and antiestrogen drugs. buy Letrozole is suitable for advanced breast cancer postmenopausal patients who have not responded to estrogen-suppressing treatment and for early breast cancer treatment. It is used to treat postmenopausal patients with advanced breast cancer and serves as a second-line treatment to follow unsuccessful antiestrogen treatment. Compared to the current standard Tamoxifen treatment, It can better prevent the risk of breast cancer recurrence.
Side effects
letrozole side effects Randomized grouping studies have shown that daily oral ingestion of 2.5mg Letrozole leads to a 33% rate of drug-related negative reactions, a percentage much lower than AG group’s 46%. Negative reactions to It are mostly mild or moderate, consisting mostly of nausea (2-9%), headache (0-7%), bone pain (4-10%), hot flashes (0-9%) and weight gain (2-8%). Other uncommon side effects include constipation, diarrhea, itching, rash, joint pain, chest pain, abdominal pain, fatigue, insomnia, dizziness, edema, high blood pressure, arrhythmia, thrombosis, dyspnea, vaginal bleeding, etc.
letrozole dosage bodybuilding

Letrozole is one of a series of novel drugs targeting aromatase inhibitors. Male bodybuilders and athletes have found Letrozole to have the ability to mitigate anabolic/androgenic steroid-related estrogenic side effects such as gynecomastia, fat accumulation, and water retention among other side effects. It is the most effective estrogen-lowering drug developed to date and has a more potent effect than non-selective first-generation aromatase inhibitors such as Teslaq and Amiloride.

A dose of 2.5 mg of letrozole per tablet is sufficient to reduce estrogen levels by an average of 78% during clinical use, according to product information. The drug also typically maintains fairly effective properties at lower doses. The product insert states that at low doses of 0.1 and 0.5 mg, respectively, they produced 75 and 78% estrogen suppression, respectively, in many patients in clinical studies. The recommended doses also caused the desired level of suppression in almost all patients. Therefore many people may not need the 2.5mg dose and may only need half a tablet to get good results.

The medically recommended dose of 2.5mg per day reduces the problem of elevated estrogen in anabolism, with weekly intakes of up to 800mg of testosterone and body fat under 15% only 1.25mg is sufficient to suppress estrogen, with weekly intakes of 1000mg or more of testosterone usually 2.5mg of letrozole per day, the exact dosage is adjusted according to the body type, so please refer to the specific case for a more detailed analysis.

letrozole powder Chemical Properties

Melting point 181-183°C
Boiling point 563.5±60.0 °C(Predicted)
density 1.21±0.1 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO: >50mg/mL
form White powder
pka 1.52±0.11(Predicted)
color white to off-white
Merck 14,5450
InChI InChI=1S/C17H11N5/c18-9-13-1-5-15(6-2-13)17(22-12-20-11-21-22)16-7-3-14(10-19)4-8-16/h1-8,11-12,17H
InChIKey HPJKCIUCZWXJDR-UHFFFAOYSA-N
SMILES C(C1=CC=C(C=C1)C#N)(C1=CC=C(C=C1)C#N)N1C=NC=N1
CAS DataBase Reference 112809-51-5(CAS DataBase Reference)

https://en.wikipedia.org/wiki/Letrozole

Price(USD)

$200/100g $900/500g $1700/1kg

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