Nandrolone is an anabolic androgenic steroid (AAS) derived from testosterone, which has significant protein anabolic capacity while avoiding excessive androgen-like side effects. It was launched by the Dutch pharmaceutical company Organon in 1962, mainly for the treatment of refractory anemia and weight and muscle loss caused by various wasting diseases. Later, It was introduced into the sports world and became one of the widely used drugs in the bodybuilding world.
Chemical structure and mechanism of action of Nandrolone
It is a product obtained by modifying the C19 position of the testosterone molecule. Its structure is close to progesterone (progestogen), and it has the characteristics of both progestogen and androgen. Nandrolone naturally produces trace amounts of hormones in the human body, but its metabolic clearance ability varies from person to person. Therefore, in strict drug tests, even athletes who have not used It drugs may be tested positive due to the naturally produced Nandrolone metabolites in the body.
Nandrolone in bodybuilding
It is mainly used for muscle and girth gain in the fitness field, especially in the bodybuilding world, where the “bread and butter cycle” consisting of Nandrolone, Dianabol and testosterone is very popular. This combination is called “Deca-Durabolin” (Deca for short), and its active ingredient is Nandrolone. It has a protein anabolic capacity that is about 30% stronger than testosterone, while avoiding the excessive androgen-like side effects such as hair loss, acne and prostate enlargement, making it the first choice for those with these symptoms.
Nandrolone Side effects
Although Nandrolone is considered one of the safest steroids, its side effects still need to be noted. Common side effects include hypersexuality or hyposexuality, promotion of breast development, etc. In addition, It may cause water and fat storage, which may not be a desirable effect in some cases.
Views and use of Nandrolone by fitness people
Fitness people have complex and diverse attitudes towards the use of It. Some people believe that Nandrolone can help them gain muscle quickly in a short period of time, especially when they encounter training bottlenecks. However, the health risks of long-term use of steroids cannot be ignored, including damage to the liver and kidneys, cardiovascular problems, etc. Therefore, fitness people need to carefully weigh the pros and cons when using It.
Nandrolone powder Chemical Properties
Melting point 120-125 °C
alpha D22 +55° (c = 0.93 in chloroform)
Boiling point 357.38°C (rough estimate)
density 1.0528 (rough estimate)
refractive index 1.4800 (estimate)
Fp 2℃
storage temp. Controlled Substance, -20°C Freezer
solubility Acetonitrile: 1 mg/ml; Ethanol: 1 mg/ml; Methanol: 1 mg/ml
form A crystalline solid
pka 15.06±0.40(Predicted)
color Dimorphic crystals from CH2Cl2/Et2O
Water Solubility 3.09g/L(25 ºC)
Merck 6365
BRN 2055849
InChIKey NPAGDVCDWIYMMC-IZPLOLCNSA-N
CAS DataBase Reference 434-22-0(CAS DataBase Reference)
More Introduction：https://en.wikipedia.org/wiki/Nandrolone
