what is Nandrolone decanoate, sold under the brand name ROLON among others, is an androgen and anabolic steroid (AAS) medication which is used primarily in the treatment of anemias and wasting syndromes, as well as osteoporosis in menopausal women. It is given by injection into muscle or fat once every one to four weeks.
nandrolone decanoate side effects
side effects of nandrolone decanoate may include symptoms of masculinization like acne, increased hair growth, and voice changes.The medication is a synthetic androgen and anabolic steroid and hence is an agonist of the androgen receptor (AR), the biological target of androgens like testosterone and dihydrotestosterone (DHT).It has strong anabolic effects and weak androgenic effects, which give it a mild side effect profile and make it especially suitable for use in women and children. It is a nandrolone ester and a long-lasting prodrug of nandrolone in the body.nandrolone decanoate for bodybuilding
Nandrolone decanoate was first described in 1960 and was introduced for medical use in 1962. It was the second nandrolone ester to be introduced, following nandrolone phenylpropionate (NPP) in 1959, and is one of the most widely used nandrolone esters. It is also one of the most widely used AAS worldwide.In addition to its medical use, nandrolone decanoate is used to improve physique and performance, and is said to be the most widely used AAS for such purposes.
Description
Nandrolone decanoate, also known as nandrolone caprinate, is an alkylated anabolic steroid indicated in the management of anemia of renal insufficiency and as an adjunct therapy in the treatment of senile and postmenopausal osteoporosis. The process for creating esters of [nandrolone] was patented in Spain in 1959 and in 1960, it was described as having a long duration of action and strong anabolic effect compared to nandrolone and other esters. It was granted FDA approval on 5 October 1962.
Chemical Properties White or almost white, crystalline powder.
Uses Nandrolone Decanoate is an anabolic steroid. It is used in the treatment of osteoporosis in postmenopausal women. It is also used for some aplastic anemias. Control led Substance.
Definition ChEBI: Nandrolone decanoate is a steroid ester.
World Health Organization (WHO)
Nandrolone decanoate, an anabolic steroid, was introduced in 1962. In 1982, low dosage preparations were prohibited in Bangladesh due to inadmissible promotion of products containing anabolic steroids for malnourished children. Higher dosage preparations of It remain available in many countries, including Bangladesh, for several highly specific but limited indications that apply to patients with chronic debilitating and emaciating diseases, particularly associated with neoplasia and some types of aplastic anaemia.
General Description Nandrolone decanoate,17β-hydroxyestr-4-en-3-one 17-decanoate, has been used inthe management of certain anemias, but the availability oferythropoietin has greatly reduced this use.
Biochem/physiol Actions Compared to testosterone propionate, It is considered to have strong anabolic effects but weak androgenic effects (potency ratios of 3.29–4.92 and 0.31–0.41). In particular, nandrolone esters are thought to have the highest ratio of anabolic to androgenic effects of any AAS. The low androgenicity of It is thought to be due to the fact that nandrolone is inactivated by 5α-reductase via transformation into the low-affinity androgen receptor (AR) ligand 5α-dihydronandrolone. This is thought to result in a lower incidence and magnitude of side effects.Nandrolone decanoate (ND) injection has been classified as a Schedule III controlled substance under the Anabolic Steroids Control Act of 1990. Due to serious health risks, the nonmedical use of AASs is banned by most sports organizations.
Safety Profile
Experimental reproductiveeffects. When heated to decomposition it emits acridsmoke and irritating fumes.
Veterinary Drugs and Treatments The principle use of nandrolone in veterinary medicine has been to stimulate erythropoiesis in patients with certain anemias (e.g., secondary to renal failure, aplastic anemias). It has also been suggested for use as an appetite stimulant.
nandrolone decanoate injection Chemical Properties
Melting point 33-37°C
Boiling point 483.46°C (rough estimate)
alpha 32 º
density 1.0406 (rough estimate)
refractive index 1.4700 (estimate)
storage temp. 2-8°C
solubility 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.8 mg/mL
form powder
color white to light yellow
Water Solubility 664ug/L(37 ºC)
InChIKey JKWKMORAXJQQSR-MOPIKTETSA-N
SMILES [C@@]12([H])CC[C@H](OC(=O)CCCCCCCCC)[C@@]1(C)CC[C@]1([H])[C@@]3([H])CCC(=O)C=C3CC[C@@]21[H] |&1:0,4,17,21,23,33,r|
CAS DataBase Reference 360-70-3
