Description Tianeptine sodium salt is a structurally novel, serotonin specific antidepressant. It is useful in the treatment of neurotic and reactive depressions, as well as depressive states accompanied by anxiety. Tianeptine (sodium salt) is an analytical reference standard categorized as an opioid. Tianeptine has been abused and associated with overdose and death. Formulations containing tianeptine have been used in the treatment of depression. This product is intended for use in analytical forensic applications. This product is also available as a general research tool .
Uses
Tianeptine sodium salt powder is a tricyclic compound with psychostimulant, anti-ulcer and anti-emetic properties. And Tianeptine sodium salt hydrate has been used as a selective serotonin reuptake enhancer (SSRE) positive control during serotonin transporter (SERT) assay in human embryonic kidney 293 cell lines. Tianeptine (INN) (Stablon, Coaxil, Tatinol) is a SSRE drug used for treating major depressive episodes (mild, moderate, or severe). Tianeptine commonly used for depression. It is also used for pain, asthma, anxiety, and many other conditions, but there is no good scientific evidence to support these other uses.
Biochem/physiol Actions Tianeptine is a tricyclic antidepressant that enhances serotonin uptake. This drug can affect neuroprotection, neuronal excitability, memory and anxiety. However, tianeptine is not linked to adverse psychomotor, cognitive, cardiovascular, sleep and bodyweight effects. The drug has a low tendency for abuse and has a positive pharmacokinetic profile.
Appearance White to pale yellow solid.
Biochem/physiol Actions
Tianeptine sodium tablets is a tricyclic antidepressant that enhances serotonin uptake. This drug can affect neuroprotection, neuronal excitability, memory and anxiety. However, tianeptine is not linked to adverse psychomotor, cognitive, cardiovascular, sleep and bodyweight effects. The drug has a low tendency for abuse and has a positive pharmacokinetic profile.
Tianeptine is least involved in drug interaction as it is not metabolized by cytochrome P450 system in the liver. In hippocampus and amygdala, tianeptine is involved in glutamatergic transmission processes and elicits neuroplasticity.
Tianeptine sodium salt Side Effects
The usual tianeptine sodium dosage is about 12 mg thrice a day for average weights, but others can even go for 25mg thrice a day. The typical side effects include dizziness, headaches, abdominal pains, constipation, tianeptine withdrawals, dream changes, as well as nausea. Renal failure patients and elderly patients need to take minimal dosages lest they suffer from complications. Always inform your doctor in case you experience any tianeptine withdrawal symptoms.Liver Toxicity:Studies have shown that this Antidepressant increases the chances of liver toxicities.
Decrease of Emotional Memory
The current research showed that patients who had taken tianeptine nootropic have become less accurate at interpreting facial expressions as well as had reduced memory correlated to emotions/ they also showed lowered attention vigilance associated with positive stimuli.
Melting point 1800C
storage temp. Desiccate at RT
solubility DMSO: ≥20mg/mL
form solid
color white to tan
Merck 14,9420
Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 2 months.
InChIKey ZLBSUOGMZDXYKE-UHFFFAOYSA-M
SMILES C1(NCCCCCCC([O-])=O)C2C=CC=CC=2N(C)S(=O)(=O)C2C=C(Cl)C=CC1=2.[Na+]
CAS DataBase Reference 30123-17-2(CAS DataBase Reference)
More Introduction:https://en.wikipedia.org/wiki/Tianeptine
