Thymalin is a polypeptide complex isolated from the thymus and regulating the functions of the immune system, effective in therapy of acute respiratory syndrome, chronic obstructive bronchitis, and other immunopathology. Thymalin increases functional activity of T lymphocytes, but the targeted molecular mechanism of its biological activity requires further study. We studied the influence of thymalin on differentiation of human hematopoietic stem cells (HSC) and expression of CD28 molecule involved in the implementation of antiviral immunity in COVID-19 infection.
It was found that thymalin peptide reduced the expression of CD44 (stem cell marker) and CD117 (molecule of the intermediate stage of HSC differentiation) by 2-3 times and increased the expression of CD28 (marker of mature T lymphocytes) by 6.8 times. This indirectly indicates that thymalin stimulated differentiation of CD117+ cells into mature CD28+T lymphocytes. It is known that in patients with severe COVID-19, the number of CD28+, CD4+, CD8+T lymphocytes in the blood decreased, which attested to a pronounced suppression of immunity. It is possible that the antiviral effect of thyma consists in compensatory stimulation of HSC differentiation into CD28+T lymphocytes at the stage of immunity suppression in unfavorable course of viral infection. Thyma can be considered as an immunoprotective peptide drug for the prevention of COVID-19.
Description
Thymalin is a synthetic version of thymulin, which involve in the regulation of inflammation and pain. Research shows that thymalin can effectively boost immune function, fight heart disease and regulate sleep-wake cycles. It is also of some interest in aging research . Because of its ability to reduce mortality from any cause in mouse models and extend life.
Additional informations:
The product (substance) isn’t a food or diet supplement and is not suitable for human consumption.
Keep out of children’s reach
Keep container tightly closed.
Store in a dry, cool and shaded place; protect from moisture.
Store only in the original container.
Avoid contact during pregnancy and breast feeding.
Consult a doctor in the event of feeling unwell or having adverse effects related to the contact with the substance.
More Introduction:https://en.wikipedia.org/wiki/Thymulin
