Tadalafil is a pill used to treat prostate problems and erectile dysfunction. However, many bodybuilders also use it as a fitness supplement.Widely known by its brand name Cialis, Tadalafil is a vasodilator that increases blood flow, similar to the effects seen before a workout. This increased blood flow leads to better pumping during training.
Tadalafil Benefits
Bodybuilders who use Tadalafil as a pre-workout supplement do so because they feel the benefits of vasodilation throughout the body. This is because there are many benefits of promoting and optimizing blood flow to the muscles. Increased blood flow ensures that fresh oxygen reaches the muscles faster, while waste products from training reach the kidneys faster. This greatly improves recovery time and soreness after training. As a result, bodybuilding professionals and enthusiasts can work out further and more frequently in the gym.
This is why drugs like Tadalafil (Cialis) and even Sildenafil (viagra) have entered the fitness arena.
Tadalafil Dosage
There are different doses of Tadalafil pills available in the market ranging from 2.5 mg to 25 mg. However, taking the maximum dose may not be the wisest idea. Some bodybuilders claim that a 10mg dose has “health benefits such as lower blood pressure and improved pumping throughout the body”. It is also recommended to start with 5mg and then increase to 10mg. Otherwise, side effects such as headaches and flushing can become a problem.
Tadalafil Side Effects
1. Gastrointestinal discomfort: Tadalafil tablets are commonly used in the treatment of erectile dysfunction in men, which can increase the blood supply to the cavernous sinus of the penis, and can enhance the hardness of penile erection. However, gastrointestinal discomfort, such as abdominal pain, diarrhea, nausea, and loss of appetite, may occur after taking the tablets, which can usually be gradually returned to normal.
2. Neurological reactions: Tadalafil tablets mainly through the inhibition of phosphodiesterase, so that the local tissue congestion to achieve the therapeutic effect, the patient’s spirit may be more concentrated, excitement, etc., may appear sleep difficulties, flushing, fainting and other neurological reactions.
Tadalafil Chemical Properties
Melting point 298-300°C
alpha D20 +71.0°
Boiling point 679.1±55.0 °C(Predicted)
density 1.51±0.1 g/cm3(Predicted)
Fp 2℃
storage temp. Sealed in dry,2-8°C
solubility DMSO: soluble20mg/mL, clear
form powder
pka 16.68±0.40(Predicted)
color white to beige
optical activity [α]/D +68 to +78°, c = 1 in chloroform-d
BCS Class 4
Stability: Unstable in Methanol
Bioavailability Varies
Protein binding 94%
Metabolism Liver (predominantly CYP3A4)
Metabolites Catechol metabolite
Onset of action 30 minutes
Elimination half-life 17.5 hours
Excretion Feces (~61%), urine (~36%)[5]
More Introduction:https://en.wikipedia.org/wiki/Tadalafil
