Introduction: SS31 peptide is a cardiolipin peroxidase inhibitor and mitochondrial targeting peptide. It can improve left ventricular and mitochondrial function. SS-31 peptide can reduce mitochondrial dysfunction and oxidative damage in human trabecular meshwork cells. It can protect iHTM and GTM (3) cells from sustained oxidative stress induced by H2O2. Phase II clinical trials for the treatment of chronic heart failure and mitochondrial myopathy are ongoing.
H-Dmt-D-Arg-Phe-Lys-NH2 (Dmt:2,6-dimethyl-L-tyrosine) is an opioid peptide derived from dermomorphin. It has strong analgesic effects and good cell membrane permeability. After in-depth mechanistic studies, the mitochondrial targeting antioxidant peptide SS31 (H-D-Arg-Dmt-Lys-Phe-NH2) was discovered. SS-31 has therapeutic effects on diseases related to free radicals such as ischemia-reperfusion injury, neurodegenerative diseases, heart failure, muscle aging, etc. SS-31 is a molecule targeting mitochondria. It interacts with cardiolipin to reactivate ischemic mitochondria. SS-31 is also a cell-penetrating peptide.
