Vosilasarm, also known by the development codes RAD 140 and EP0062 and by the black-market name Testolone or Testalone, is a selective androgen receptor modulator (SARM) which is under development for the treatment of hormone-sensitive breast cancer. It is specifically under development for the treatment of androgen receptor-positive, estrogen receptor-negative, HER2-negative advanced breast cancer. Vosilasarm was also previously under development for the treatment of sarcopenia (age-related muscle atrophy), osteoporosis, and weight loss due to cancer cachexia, but development for these indications was discontinued. The drug is taken by mouth.
Uses
RAD140 is a potent, orally bio-available, and non-steroidal selective androgen receptor modulator (SARM) for the treatment of conditions such as muscle wasting and breast cancer.
benefits Significant and selective anabolic effect on muscles and bones, without strong androgenic adverse effects on other organs
Has strong neuroprotective effects, may be effective in preventing Alzheimer’s disease and related neurodegenerative disorders
Has the potential to fight breast cancer
Can help treat serious diseases associated with muscle loss
Can help protect brain cells and their proper functions
May help in the treatment of osteoporosis
Helps build and maintain muscle mass
May help reduce excess fat
RAD 140 Side effects
In animal studies, RAD 140 has shown to be safer than testosterone replacement therapy, when administered to rats. This is impressive, given the general positive safety profile of testosterone, hence its FDA-approved status.
However, in humans there appears to be a different trend, with RAD 140 demonstrating harsher side effects.
Suppressed levels of natural Testosterone
Anxiety, depression
Nausea and vomiting
Possible liver toxicity
Abnormal body hair growth in women
Excessive hair loss in men (which stops after the end of RAD140 treatment)
The long-term effects of RAD140 are unknown
Dosage forms
RAD140 is the most effective when used in smaller amounts. It is essential that you follow an appropriate dosage for the drug. Nothing is beneficial in excessive amounts. Since it is a SARM, it is also recommended that you use it in cycles, starting with small dosages and moving upwards.
The beginner level dosage is 5 mg every day for a week. This will allow your body to adjust and build tolerance for more as you start your daily workouts. You can later change the dosage to 10 mg every day.
The first cycle is a trial period. It should be fully completed, or the results may not turn out at optimal capacity. This first cycle should be followed for a maximum of 6 weeks. Alternatively, if you have used SARMs before, especially RAD140, then you can start with 10 mg a day for the first week and move up to 15 mg for a seven-week cycle.
More experienced
consumers, who have already tried RAD140 for several cycles, can start their dosage directly at 20 mg a day for a 10-week cycle. It is essential that you discontinue the dosage if you experience any side effects at any moment in your cycle. However, you must build up your cycles if there are no side effects.
For women, the starting point for the first cycle should be 5 mg a day, which can be moved up to 10 mg a day for a cycle of 6 weeks. It is also recommended that you take the dosage in one go and not in intervals throughout the day.
It is also recommended by professionals that you do PCT since RAD140 increases the natural amount of testosterone in your body. The PCT cycle should be done for at least 4 to 6 weeks. This is done to prevent your body from any side effects. You can take 20mg of Clomid or Nolvadex every day, reducing it to 10 mg, for your PCT cycle.
Clinical claims and research
As no results of RAD140 clinical trials in humans are yet known, it is not yet possible to speak of frequently used or safe clinical doses of RAD140 in humans. However, a clinical study performed in young primates showed that even a low dose of 0.1 mg RAD140 per kg body weight has already led to strong anabolic effects and a significant increase in muscle mass. This suggests that RAD140 is a very potent SARM, which begins to show its strong anabolic effects already from relatively low doses.
In various bodybuilding forums and discussions on the internet, bodybuilders and users who have used (abused) RAD140 to build muscle mention 10 mg of RAD140 daily as a basic and sufficient dose to achieve significant results; and a cycle duration of 6-8 weeks. In the case of more experienced (hardcore) bodybuilders, there is talk of an optimal dose of 20 mg RAD140 per day and a cycle duration of 8 to 10 weeks. However, none of these doses are based on any scientific research.
We emphasize that RAD140 is not an approved nutritional supplement or stimulant for athletes. It is an experimental substance that is still under investigation and not all of its side effects may be known. Keep in mind that RAD140, like all our other products, is sold solely for scientific and research clinical use.
Mode of action
RAD 140 is a powerful SARM and its characteristics are much similar to those of steroids. RAD 140 powder has very unique working mechanism as they don’t have androgenic properties, but they carry very similar anabolic properties to testosterone and other steroids. As a result, your body will get an enhanced capacity to increase the amount of protein synthesis, which is a necessary part of building muscle mass. With boosted protein synthesis, your body will work towards building more muscle with reduced recovery time. It means that you can work super hard in the gym with better and faster recovery time after workout. As RAD 140 is not an androgen, it doesn’t come with the negative effects like steroids. Androgens can affect your body’s natural production of testosterone in the long run and can have devastating impacts on your internal organs and fertility levels.
Sarm RAD140 Chemical Properties
Melting point 179-183oC
Boiling point 687.7±65.0 °C(Predicted)
density 1.41±0.1 g/cm3(Predicted)
storage temp. -20°C Freezer
solubility Chloroform (Slightly), DMSO (Slightly)
pka 13.76±0.20(Predicted)
form Solid
color White
InChI InChI=1S/C20H16ClN5O2/c1-11-16(8-7-15(10-23)17(11)21)24-18(12(2)27)20-26-25-19(28-20)14-5-3-13(9-22)4-6-14/h3-8,12,18,24,27H,1-2H3/t12-,18+/m0/s1
InChIKey XMBUPPIEVAFYHO-KPZWWZAWSA-N
SMILES C(#N)C1=CC=C(N[C@@H](C2=NN=C(C3=CC=C(C#N)C=C3)O2)[C@@H](O)C)C(C)=C1Cl
CAS DataBase Reference 1182367-47-0
More Introduction：https://en.wikipedia.org/wiki/Vosilasarm
