NA Semax,N-Acetyl Semax Acetate

Description

N-Acetyl Semax Amidate. (commonly called NA Semax buy) is a modified version of the peptide Semax. It has gained quite a bit of attention in recent years due to its potential cognitive and neuroprotective properties. NA Semax Amidate has been studied fairly extensively for anxiolytic, nootropic and other effects in lab settings.

Structure and Modifications
NA Semax Amidate is a modified version of Semax that has had an acetyl group added to the N-Terminus end of the peptide chain, and an amide group added to the C-Terminus side. These modifications work together to enhance the peptide’s overall stability as well as bioavailability, increasing its potential in biological studies and theoretically enhancing its potential in crossing the blood-brain barrier as well as increasing its interactions with neurotransmitters.

The amino acid sequence of buy NA Semax Amidate is Ac-Met-Glu-His-Phe-Pro-Gly-Pro-NH2.

Pharmacokinetics and Pharmacodynamics
NA Semax Amidate, thanks to its modifications, has a longer half-life compared to the base form of Semax, meaning it remains active for a longer period. This is thanks largely due to its enhanced stability which resists degradation by enzymes and other factors. This peptide has been studied to modulate the expression of certain genes involved in neurotransmission, especially those in the hippocampus and limbic reticular complex areas, which are parts of the brain critical for both learning and memory.

Cognitive and Neuroprotective Effects

NA Semax Amidate’s cognitive-enhancing effects are a strong focus of clinical studies around this peptide. This includes improved memory and attention, as well as learning. It has also been shown to have strong neuroprotective properties, including helping to protect the brain against oxidative stresses and inflammation. The method of action of these effects are thought to be due to its ability to increase the expression of BDNF aka brain-derived neurotrophic factor, as well as other neutrophic factors.

Comparison to Adamax
Adamax is yet another modified version of Semax, and it has an additional acetate group added to the N-Terminus. Both NA Semax Amidate and Adamax have enhanced stability and bioavailability, Adamax is often considered more potent and longer lasting. However, Adamax has many issues with synthesis and is difficult to find in lyophilized form. Additionally, many versions of Adamax found from various vendors is the TFA salt form, which contains high amounts of Trifluoroacetic acid.

Comparison to NA Selank Amidate
NA Selank Amidate is a similarly modified version of Selank. Both NA Semax Amidate and NA Selank Amidate are similarly structured and modified, they are studied for very separate effects. NA Selank Amidate is often researched for more anxiolytic and anti-inflammatory effects, while NA Semax Amidate is primarily researched around cognition and neuroprotection.