what is Adrenocorticotropic hormone (ACTH; also adrenocorticotropin, corticotropin) is a polypeptide tropic hormone produced by and secreted by the anterior pituitary gland. It is also used as a medication and diagnostic agent. ACTH is an important component of the hypothalamic-pituitary-adrenal axis and is often produced in response to biological stress (along with its precursor corticotropin-releasing hormone from the hypothalamus). Its principal effects are increased production and release of cortisol and androgens by the cortex and medulla of the adrenal gland, respectively. ACTH is also related to the circadian rhythm in many organisms.buy adrenocorticotropic hormone ACTH peptide
Deficiency
ACTH is an indicator of secondary adrenal insufficiency (suppressed production of ACTH due to an impairment of the pituitary gland or hypothalamus, cf. hypopituitarism) or tertiary adrenal insufficiency (disease of the hypothalamus, with a decrease in the release of corticotropin releasing hormone (CRH)). Conversely, chronically elevated ACTH levels occur in primary adrenal insufficiency (e.g. Addison’s disease) when adrenal gland production of cortisol is chronically deficient. In Cushing’s disease a pituitary tumor is the cause of elevated ACTH (from the anterior pituitary) and an excess of cortisol (hypercortisolism) – this constellation of signs and symptoms is know as Cushing’s syndrome.adrenocorticotropic hormone peptide for sale
Indications
Adrenocorticotropic hormone (ACTH), or corticotropin, a peptide of 39 amino acids, is first synthesized as a larger precursor from which ACTH is derive by proteolytic cleavage. ACTH stimulates production of glucocorticoids from the adrenal cortex. Release of ACTH depends on diurnal rhythms with serum levels highest in the early morning. Secretion of this peptide also increases under stress. It is easier and less expensive to treat patients having adrenocortical insufficiency with glucocorticoid replacement therapy than it is to use ACTH.
Therefore, use of ACTH (Acthar) is restrict to diagnosis; a shorter 24–amino acid analogue (Cosyntropin) is also used. Intravenous administration of ACTH should result in peak plasma levels of glucocorticoids within 30 to 60 minutes if the adrenal gland is functional. Prolonged administration of ACTH in a repository form, however, may be necessary to stimulate steroid production, because ACTH has long-term trophic effects on adrenal cells in addition to the rapid stimulation of steroid production. If the cause of steroid deficiency is at the level of the pituitary gland, ACTH should eventually stimulate steroid production.
Biological Functions
The main function of Adrenocorticotropic hormone (ACTH) is to regulate the glucocorticoid (steroid) hormone cortisol. Cortisol releas by the adrenal gland. It regulates blood pressure, blood sugar, the immune system, and the response to stress. This test can help find the causes of certain hormone problems adrenocorticotropic hormone function
Health Hazard Adrenocorticotropic Hormone (ACTH;Adrenocorticotropin; corticotropic hormone): (1)Maintenance of adrenal cortex;(2)Promotes secretion of steroids, oxidative phosphorylation in adrenal cortex;(3)Mobilizes and increases oxidation of free fatty acid in adipose tissue;(4)Increases gluconeogenesis in liver; increases cyclic adenosine monophosphate (AMP) in adrenal cortex;Decreases urea formation in liver.
Biochem/physiol Actions Stimulates synthesis and secretion of glucocorticoids by adrenal cortex.
Producing and consuming organs The anterior pituitary produces ACTH. It consider a tropic hormone. Tropic hormones indirectly affect target cells by first stimulating other endocrine glands. Corticotropin-releasing hormone (CRH) release from the hypothalamus, which stimulates the anterior pituitary to release adrenocorticotropic hormone (ACTH). ACTH then acts on its target organ, the adrenal cortex.
Adrenocorticotropic hormone Chemical Properties
storage temp. −20°C
form powder
InChIKey XFBDTKGDXZDJAN-WODOTNDISA-N
Safety Information
Hazard Codes Xn
Risk Statements 20/21/22-40
Safety Statements 22-36
WGK Germany 3
More Introduction:https://en.wikipedia.org/wiki/Adrenocorticotropic_hormone
