Description ACE-031 peptide buy is a fusion protein comprised of the extracellular domain of the human ActRIIB linked to the Fc (hinge CH2 and CH3 domains) portion of the human immunoglobulin G1 (IgG1). It binds avidly to myostatin and other negative regulators of muscle mass and inhibits their biological effects by preventing signaling through the endogenous receptor.
ace-031 peptide benefits It is a muscle modulator that combines with myostatin and other negative regulators of muscle mass to promote muscle growth. It is a fusion protein of activin receptor type IIB (ActRIIB) and IgG1-Fc that binds to myostatin and related ligands. Clinical studies have shown that It can be used to treat myopathies such as Duchenne muscular dystrophy (DMD).
Side effects ACE-031, a soluble ACVR2B receptor, was prematurely terminated due to severe adverse effects, including nosebleeds, gum bleeding, telangiectasia, and erythema attributed to cross-inhibition of BMP9 and BMP10, ligands involved in endothelial cell function. In addition, a 43% decrease in serum follicle-stimulating hormone (FSH), whose synthesis is stimulated by activins, was observed in healthy, postmenopausal women who received a single dose (3 mg/kg) of It, which caused a near-maximal suppression of activin signaling.
Research Ramatercept (ACE-031 for sale) is a soluble form of ACVR2B developed by Acceleron Pharma to treat Duchenne Muscular Dystrophy (DMD). Despite encouraging results of both the animal study, in which ACE-031 significantly increased both type 1 and type 2 muscle fiber cross-sectional area in young mice, and phase 1 clinical study in healthy postmenopausal women, in which ACE-031 injection (3 mg/kg) significantly increased total body lean mass and thigh muscle volume, subsequent phase 2 clinical trial in patients with DMD was terminated due to occurrence of non-muscle-related severe adverse events including nosebleed, gum bleeding, telangiectasia, and/or erythema, halting further development of the drug.
More Introduction:https://en.wikipedia.org/wiki/Decoy_receptors#ACE-031
