Mesterolone has anti-SHBG (sex hormone-binding globulin) properties, which are actually particularly important—especially toward the end of each cycle, when large amounts of androgens are bound by SHBG and thus cannot exert their anabolic effects. At this point, a substance with anti-SHBG properties is needed to counteract this binding. However, mesterolone’s anti-SHBG (sex hormone-binding globulin) properties are not really worth mentioning, as its effect in this regard is so weak that it can practically be ignored.
Mesterolone can be used at any stage of a cycle. Its four main characteristics are:
First: Anti-estrogenic
Mesterolone is unlikely to promote muscle growth because of its anti-estrogenic properties. Generally speaking, anti-estrogens do not promote muscle growth; they are more often used to maintain current condition.
Second: Fat Loss
Although mesterolone has fat-burning effects, its fat-burning ability is inferior to that of oxandrolone and trenbolone.
Third: No Hepatotoxicity
Structurally, mesterolone (C1-methylated dihydrotestosterone) is very fragile and is easily metabolized. For example, if you take 75 milligrams, less than 1 to 2 milligrams may actually be absorbed. Once in the body, its bioavailability is very poor. It is metabolized and inactivated very quickly.
Fourth: Gonadal Preservation
Mesterolone helps preserve gonadal function. It is primarily used during bridging phases—at the end of a cycle or during PCT—to prevent the loss of gains. To retain these gains, small doses of various compounds are used, including mesterolone; however, mesterolone is actually a poor choice. When used at low doses, mesterolone can restore gonadal function. For example, during a cycle where we’ve injected large amounts of androgens—such as nandrolone or Deca-Durabolin—our testicles may virtually stop secreting testosterone on their own, effectively “going on strike.” When we end the cycle, we need our testicles to resume functioning. During a cycle, the testes are inactive, and recovery is very slow. To restore testicular function, mesterolone can help restart gonadal activity. The dose must be kept below 50 mg per day; it must not be too high, as doses exceeding 50 mg per day can actually have the opposite effect.