Epithalon-livagen peptide is a synthetic peptide made of four amino acids (alanine, glutamic acid, aspartic acid, and glycine), that is based on a natural peptide called epithalamin extracted from the pineal gland. It was synthesized by Vladimir Khavinson, a Russian professor and gerontologist, whose research focused on the development of peptide preparations used to restore function in various organs in order to prevent and reverse the aging process. He is currently the Director of the Saint Petersburg Institute of Bioregulation and Gerontology.
Epithalon-livagen benefits
As a result of Epitalon’s effect on telomerase production, the benefits are unique and far-reaching and include:
Increases lifespan by lengthening telomeres in human cells|
Promotes deeper sleep
Delays and prevents of age-related diseases such as cancer, heart disease, and dementia
Acts as an antioxidant by reducing lipid oxidation and ROS (Reactive oxygen species) along with normalizing T cell function
Improves skin health and appearance
Heals injured and deteriorating muscle cells
Restores and normalizes melatonin levels in those who have lost some pineal function due to aging
Can increase resistance to emotional stress
Epithalon-livagen side effects and Mechanism of action
Telomerase activator peptide Epithalon-livagen directly stimulates cells in the body to produce a telomerase enzyme, that renew and extends telomeres at the ends of chromosomes. This ultimately leads to a slowing of the aging of cell populations, and the aging of cell populations correlate with the overall physical aging of an organism. Clinical studies conducted with Epitalon have shown that administration of Epitalon to mammals has not only reversed the symptoms of aging but also reversed many age-related diseases. Epitalon has also been shown to help restore and normalize melatonin production by the pineal gland, as well as restoring the normal circadian rhythm of cortisol production, both of which result in better sleep at night.epithalon peptide
Side effects Epithalon side effects are very uncommon.
Side effects associated with epithalon may include the following:
Diarrhea Difficulty sleeping Fatigue Flu-like symptoms Headache Irregular heartbeat Joint pain Nausea
Clinical
claims and research Tetrapeptide Epithalon-livagen(Ala–Glu–Asp–Gly) was designed on the basis of Epithalamin amino acid analysis and synthesized at the Laboratory of Peptide Chemistry of the St. Petersburg Institute of Bioregulation and Gerontology.The geroprotective activity of Epitalon was studied in 3 strains of D. melanogaster. Epitalon increased the life-span of imagoes significantly by 11–16% when applied at unprecedentedly low concentrations-from 0.001*10-6 to 5*10-6 wt% of the culture medium. The effective concentrations of Epitalon were 16,000-80,000,000 times lower than those of melatonin. In another experiment, the mean life-span of female VES and male NA-flies increased under the influence of Epitalon by 26%. aIn NA- females the mean life-span grew by 35% and in NA- males, by 29%.
In our recent study the geroprotective effect of long-term Epitalon administration in female CBA mice was demonstrated.54 The number of mice that survived the age of 24 months increased 4 times under Epitalon influence as compared to the controls treated with saline. The bioregulator slowed down aging of the reproductive function, decreased physical activity, inhibited free radical processes, and decreased total spontaneous tumor incidence 1.7 times in female CBA mice.54 Epitalon inhibited mammary carcinogenesis and metastasis in HER-2/neu transgenic mice.55 The expression of HER-2/neu mRNA in the mammary tumors of HER-2/neu transgenic mice treated with Epitalon reduced 3.7-fold in comparison with the control animals. The administration of Epitalon inhibited colon and small intestine carcinogenesis induced by 1,2-dimethylhydrazine in rats.
Aging Interventions and Therapies || Pineal Peptides as Modulators of Aging Rattan, Suresh I S
Epitalon Chemical Properties
Boiling point 959.8±65.0 °C(Predicted)
density 1.466±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO: 250 mg/mL (495.67 mM)
pka 3.16±0.10(Predicted)
InChIKey HGHOBRRUMWJWCU-VTCOHLDGNA-N
SMILES [C@H](CC(=O)O)(C(=O)NCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](N)C |&1:0,15,24,r|
