Exemestane is an aromatase inhibitor. Aromatase inhibitors work by inhibiting the enzyme responsible for synthesizing estrogen, providing an anti-estrogen effect. Exemestane is FDA-approved for the treatment of female breast cancer, especially for patients who have not responded to tamoxifen. Bodybuilders who use steroids that aromatize often use it to inhibit estrogen-related side effects. Side effects include bitch milk, fat accumulation and water retention. Sometimes aromatase inhibitors can also be used to reduce fat and improve muscle definition. Exemestane is currently the most effective aromatase inhibitor. The most recognized anti-estrogen efficacy in clinical studies in women is 85%.
Exemestane Side Effects
Common side effects of Exemestane include hot flashes, joint pain, weakness, mood changes, depression, high blood pressure, swelling of the arms and thighs, and headaches. It also reduces the mineral density in bones, which may lead to osteoporosis and fractures in sensitive people. Some people may experience gastrointestinal problems (nausea and vomiting). When used as an anti-estrogen in the CYCLE cycle, aromatase inhibitors increase the likelihood of cardiovascular disease because the suppressed estrogen has a protective effect on the cardiovascular system. Of course, the introduction here is comprehensive, but it does not mean that it will happen once you take it. There are differences between individual human bodies. The introduction is comprehensive so that everyone can judge which drugs are problematic in C. It is recommended to seek guidance from professionals to determine the root cause of the problem.
Exemestane dosage
Exemestane is approved by the FDA for the treatment of early breast cancer in postmenopausal women. Under normal circumstances, the specification is 25 mg per day. In bodybuilding, it reduces the side effects caused by estrogen. Usually, 12.5-25 mg is taken per day. In the case of low anabolic doses, 12.5 mg is enough to control estrogen levels. Sometimes taking 12.5 mg every other day is more effective.
Exemestane Chemical Properties
Melting point 155.13°C
Boiling point 453.7±45.0 °C(Predicted)
density 1.13±0.1 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO: ≥20mg/mL
form powder
color white to off-white
optical activity [α]/D +250 to +300°, c = 1 in methanol
InChI InChI=1S/C20H24O2/c1-12-10-14-15-4-5-18(22)20(15,3)9-7-16(14)19(2)8-6-13(21)11-17(12)19/h6,8,11,14-16H,1,4-5,7,9-10H2,2-3H3/t14-,15-,16-,19+,20-/m0/s1
InChIKey BFYIZQONLCFLEV-DAELLWKTSA-N
SMILES C1(=O)C=C2[C@](C)(C=C1)[C@]1([H])[C@]([H])([C@@]3([H])[C@@](CC1)(C)C(=O)CC3)CC2=C
CAS DataBase Reference 107868-30-4(CAS DataBase Reference)
More Introduction:https://en.wikipedia.org/wiki/Exemestane
