Pinealon is a 3-amino acid peptide and shows neuroprotective properties. P prevents reactive oxygen species (ROS) accumulation and suppresses the activation of ERK 1/2. And stimulates the functional activity of the main cellular elements of brain tissue, reduces the level of spontaneous cell death. P protects the rat offspring from prenatal hyperhomocysteinemia.
in vitro P (10, 50, 100 nM; 30 min) in a dose-dependent manner prevents an increase in the ROS accumulation induced by ouabain in cerebellar granule cells.
P (10 nM; 0, 2.5, 5, 10, 20, 30 min) suppresses the activation of ERK 1/2 in rat cerebellar granule cells exposed to 500 mM homo-cysteine (HC).
pinealon peptide is a synthetic tripeptide of sequence (Glu-Asp-Arg) and purported geroprotector documented in the Russian scientific literature.
Animal research pinealon benefits
Pinealon has been shown to protect rat offspring from prenatal hyperhomocysteinemia and correspondingly improve post natal cognitive function.
And likewise maintains learning retention rats with experimentally-induced diabetes.
P has never been tested in human beings, despite assertations of its geroprotective effects in humans.pinealon peptides
Chemistry
pinealon peptide is a tripeptide composed of L-glutamic acid, L-aspartic acid, and L-arginine and is notated as Glu-Asp-Arg or EDR.
More Introduction:https://en.wikipedia.org/wiki/Pinealon
