Oxytocin free acid (9-Deamidooxytocin) is an analog of oxytocin in which the glycinamide residue at position 9 in oxyto has been replaced by a glycine residue. Oxyt is a pleiotropic, peptide hormone with broad implications for general health, adaptation, development, reproduction, and social behavior.
Uses Free acid form of oxytocin peptides , which is a hormone involved in many aspects of mammalian reproduction as well as other physiological processes such as bond pairing and cardiovascular homeostasis.
Biological Functions Oxyto is a cyclic 9-peptide that, like somatostatin, contains a ring that encompasses a disulfide bridge. Oxyto has uterotonic action, contracting the muscles of the uterus during gestation, and plays an important role in milk ejection (not milk secretion, which is regulated by the peptide hormone prolactin) from the mammary ducts into the nipples. Exogenous oxytocin most commonly is used for induction of labor, wherein it improves uterine contractions to achieve early vaginal delivery for fetal or maternal reasons (e.g., preeclampsia, Rh factor problems, pregnancy that has exceeded 42 weeks). It also finds use following delivery of the placenta, because it promotes contraction and vasoconstriction and helps to control postpartum bleeding.
Physiology
Metabolism In humans, estimates of median plasma half-life of oxytocin range from 3.2 min after a single 2 U bolus injection to 4.8 min during a 500 mU min-1 infusion. Oxyt is rapidly metabolised in the liver and kidneys, and also in the plasma during pregnancy by secreted oxytocinase (leucyl/cystinyl aminopeptidase), with some degree of metabolism also taking place in the mammary glands.
Oxytocin peptide hormone and neuropeptide normally produced in the hypothalamus and released by the posterior pituitary. Present in animals since early stages of evolution, in humans it plays roles in behavior that include social bonding, reproduction, childbirth, and the period after childbirth. Oxyto is released into the bloodstream as a hormone in response to sexual activity and during labour. It is also available in pharmaceutical form. In either form, oxytocin stimulates uterine contractions to speed up the process of childbirth.
In its natural form, it also plays a role in maternal bonding and milk production. Production and secretion of oxyto is controlled by a positive feedback mechanism, where its initial release stimulates production and release of further oxytocin. For example, when oxyt is released during a contraction of the uterus at the start of childbirth, this stimulates production and release of more oxyto and an increase in the intensity and frequency of contractions. This process compounds in intensity and frequency and continues until the triggering activity ceases. A similar process takes place during lactation and during sexual activity.
Oxytocin is derived by enzymatic splitting from the peptide precursor encoded by the human OXT gene.
The deduced structure of the active nonapeptide is:Cys – Tyr – Ile – Gln – Asn – Cys – Pro – Leu – Gly – NH2, or CYIQNCPLG-NH2.
Oxytocin free acid Chemical Properties
storage temp. -15°C
Water Solubility Soluble in water to 1mg/ml
InChIKey NFBCSRNZYJJWNB-IEIRLNIENA-N
More Introduction:https://en.wikipedia.org/wiki/Oxytocin</p>
