LGD-4033, also known by the developmental code name VK5211 and by the black-market name Ligandrol, is a selective androgen receptor modulator (SARM) which is under development for the treatment of muscle atrophy in people with hip fracture. It was also under development for the treatment of cachexia, hypogonadism, and osteoporosis, but development for these indications was discontinued. LGD-4033 has been reported to dose-dependently improve lean body mass and muscle strength in preliminary clinical trials, but is still being developed and has not been approved for medical use. The drug is taken by mouth.ibutamoren and sarm lgd-4033.
Description
LGD-4033 is a Selective Androgen Receptor Modulator (SARM). SARMs are a class of non-steroidal anabolic agents that bind androgen receptors with high affinity. LGD-4033 has been shown to provide benefits similar to traditional anabolic agents, (e.g., increased muscle mass, fat loss, and improved bone density) but with far fewer side effects (e.g., oily skin, acne, over-conversion to estrogen, etc.). Both men and women may also appreciate improved libido. All of these benefits are achieved without increasing androgen levels. Its anabolic effects are roughly the same or greater than testosterone, even at low doses. Some prescribers will recommend a trial of SARMs for low testosterone levels prior to utilizing testosterone replacement therapy.
Uses Ligandrol, also known as It, is a nonsteroidal oral drug used for the treatment of muscle wasting and osteoporosis in healthy young me.
Biological Activity
LGD-4033 is a potent nonsteroidal selective androgen receptor modulator (SARM) that binds to the androgen receptor with a Ki value of 1 nM. In animal models, LGD-4033 displays robust selectivity for muscle versus prostate tissues, anabolic activity in the muscle, and anti-resorptive and anabolic activity in bone.
LGD 4033 has been abused as a performance-enhancing drug and the identification of its in vitro metabolites has been described.
This product is intended for research and forensic applications.
Mechanism of action
LGD-4033 works by binding to androgen receptors in muscle and bone tissue and stimulating protein synthesis, thus helping to build muscle and strength, increase bone density, reduce inflammation, and promote tissue healing. In addition, it can also help improve body composition by reducing fat mass while preserving lean muscle mass.
Pharmacokinetics LGD-4033 functions by enlarging the androgen receptors, selectively. Anabolic effects on muscles and bones occur rather than negatively altering the prostate or glands, which could be caused through the use of steroids. It has recently been engaged in a study with volunteers called Phase 1 Multiple Ascending Dose. It was random,double blind testing phase in which placebo was used.The aim was to verify that the usage of It is safe and easy to use with a dosage not exceeding 22 mg daily.
LGD-4033 side effects When taken in appropriate doses, most people experience minimal side effects, if any at all. Some users may experience mild headaches, nausea, or lightheadedness, but these are generally mild and go away quickly.
Safety LGD-4033 was safe, had favorable pharmacokinetic profile, and increased lean body mass even during this short period without change in prostate-specific antigen. Longer randomized trials should evaluate its efficacy in improving physical function and health outcomes in select populations.
LGD-4033 Chemical Properties
Melting point 108 – 111°C
Boiling point 439.9±45.0 °C(Predicted)
density 1.45±0.1 g/cm3(Predicted)
storage temp. Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility Acetone (Slightly), Chloroform (Slightly, Heated), Methanol (Slightly)
pka 12.06±0.20(Predicted)
form A crystalline solid
color White to Pale Beige
Stability: Hygroscopic
InChI InChI=1S/C14H12F6N2O/c15-13(16,17)10-6-9(4-3-8(10)7-21)22-5-1-2-11(22)12(23)14(18,19)20/h3-4,6,11-12,23H,1-2,5H2/t11-,12-/m1/s1
InChIKey OPSIVAKKLQRWKC-VXGBXAGGSA-N
SMILES C(#N)C1=CC=C(N2CCC[C@@H]2[C@@H](O)C(F)(F)F)C=C1C(F)(F)F
More Introduction：https://en.wikipedia.org/wiki/Ligandrol
