Description 4-amino-2-fluoro-N-methylbenzamide powder is a novel antiandrogen drug MDV (Marek’s Disease Virus) 3100 key intermediate which is the new generation oral androgen antagonist medicine of united states drug developer Medivation company exploitation, be mainly used in treating advanced prostate cancer (CRPC) patient.
Uses It acts as a reagent in the design, synthesis and biological evaluation of novel 5-oxo-2-thioxoimidazolidine derivatives as potent androgen receptor antagonists. Also, in the preparation and structure-activity relationship of chiral benzyloxypyridinone derivatives as c-Met kinase inhibitors.
Preparation 2-fluoro-4-nitrotoluene as raw material, through potassium permanganate oxidation, the thionyl chloride chlorination, methylamine amination, and Pd/C hydrogenation reduction prepare It.
Melting point 160 – 163°C
Boiling point 320℃
density 1.234
Fp 147℃
storage temp. Keep in dark place,Inert atmosphere,Room temperature
solubility Chloroform (Slightly), Methanol (Slightly)
form Solid
pka 14.12±0.46(Predicted)
color White to Off-White
Stability: Moisture Sensitive
InChI InChI=1S/C8H9FN2O/c1-11-8(12)6-3-2-5(10)4-7(6)9/h2-4H,10H2,1H3,(H,11,12)
InChIKey XOKAXPQJUODMSH-UHFFFAOYSA-N
SMILES C(NC)(=O)C1=CC=C(N)C=C1F
